Relationship between CES2 genetic variations and rifampicin metabolism
نویسندگان
چکیده
منابع مشابه
Relationship between CES2 genetic variations and rifampicin metabolism.
OBJECTIVES Rifampicin is known to be deacetylated in vivo, resulting in its metabolite 25-desacetyl rifampicin, but the enzyme metabolizing rifampicin and the association of this process with any genetic variation have not yet been elucidated. In this study, genetic variations of a surrogate enzyme, carboxylesterase 2 (CES2), and their association with the metabolism of this drug, were investig...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2013
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkt036